| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Microsphere-Based Sustained Anti-VEGF Drugs for the Inhibition of Subfoveal Choroidal Neovascularization |
| 초록 | Vascular endothelial growth factor (VEGF) is known to play a crucial role in the pathogenesis of the the wet type of age-related macular degeneration (AMD). In this study, we confirmed the treatment ability of AMD, a disease which is caused by vascular endothelial growth factor (VEGF) signaling system, by using the PLGA(lactic-co-glycolic acid) sustained release of microspheres. Rivoceranib, a therapeutic intervention for AMD, was encapsulated through o/w single emulsion and solvent evaporation method with polymeric excipients PLGA. In vivo study, the treatment of microspheres of PLGA/rivoceranib significantly inhibits the occurrence and spread of new blood vessels in the macular degeneration model and the rivoceranib microsphere achieved sustained in vitro drug release for 50 days. |
| 저자 | LYU SIYAN, 임수연, 황위보, 김다훤, 이지현, 유빈, 신주화, 정준구, 박채은, 김병덕, 정지훈 |
| 소속 | 성균관대 |
| 키워드 | rivoceranib; subfoveal choroidal neovascularization; microsphere |
