| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Enhanced systemic siRNA delivery using a long-circulating organic/inorganic hybrid nano-hydrogel |
| 초록 |
Systemic delivery of siRNA has been mainly impeded by enzymatic degradation and poor cellular uptake. Calcium phosphate has been considered a potential candidate for siRNA delivery because of its biocompatibility and capability of entrapping siRNA in the crystal core. Based on the property of 3,4-dihydroxy-l-phenylalanine binding to the surface of the CaP crystal, dual hydrogel layers consisting of a macromolecular dextran and polyethylene glycol were introduced on the surface of the inorganic CaP core for prolonged circulation. Dextran conjugated with dopa and PEG can control the overgrowth of the CaP/siRNA core and stabilize it by dual electrically neutral hydrophilic layers of dextran and PEG, reducing hepatic accumulation and systemic clearance. The PEG-dex-dopa/CaP/siRNA improved the PK behaviors of siRNA after systemic administration, increasing its distribution to tumors and the inhibition of tumor growth by silencing vascular endothelial growth factor gene expression. |
| 저자 |
김다훤, 임수연, LYU SIYAN, 황위보, 박채은, 김병덕, 정준구, 신주화, 이지현, 유빈, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
gene delivery; calcium phosphate; 3; 4-dihydroxy-l-phenylalanine; dextran; polyethylene glycol; cancer therapy
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| E-Mail |
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