| 초록 |
In spite of polysaccharide's excellent biological activity, β-glucan has not been developed to date as a biological drug carrier by radiation. Minocycline hydrochloride (MH) is a type of semisynthetic tetracycline that can easily penetrate into the tissue and has excellent antimicrobial activity. In this study, Solutions of β-glucan were prepared by dissolving in DIW and the mixture was exposed to a gamma irradiation. Finally, the β-glucan hydrogels prepared by radiation were impregnated into an MH solution. Physical properties, such as the gel content, swelling percent and compressive strength, were also investigated. In addition, MH loaded β-glucan hydrogels prepared by this radiation technique were tested for their antibacterial activity. |
