| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
대학원생 구두발표(발표10분) |
| 제목 |
Transdermal Nano Graphene Oxide – Hyaluronic Acid Conjugate for Photo-Ablation Therapy of Skin Cancer Using NIR Laser |
| 초록 |
Nano-sized graphene oxide (NGO) has a high photothermal effect under low power near infrared (NIR) irradiation due to their effective light-to-heat conversion compared to other carbon allotropes. Hyaluronic acid (HA) has been used as an effective transdermal delivery carrier of chemical drugs and biopharmaceuticals. Here, we report transdermal NGO – HA conjugates for photo-ablation therapy of melanoma skin cancer using NIR laser. Confocal microscopy showed that NGO-HA was transdermally delivered to the cancerous skin in mice with highly expressed HA receptors and a relatively leaky structure. The NIR irradiation resulted in complete ablation of tumor tissues with no recurrence of tumorigenesis. The anti-tumor effect was confirmed by ELISA for caspase-3 activity, and histological and immunohistochemical analyses with TUNEL assay for tumor apoptosis. Taken together, we could confirm the feasibility of transdermal NGO-HA for photothermal ablation therapy of melanoma skin cancers. |
| 저자 |
정호상, 한세광, 공원호, 이민영
|
| 소속 |
POSTECH |
| 키워드 |
Graphene oxide; Hyaluronic acid; Transdermal delivery; Photothermal therapy
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| E-Mail |
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