| 초록 |
A wearable plasmonic sensor has been fabricated for molecular detection in human sweat. In this work, a patch type surface-enhanced Raman scattering materials were designed to comprise layers of silk fibroin (SF), silver nanowire (AgNW) and dermal patch (DP) that function for sweat absorption, Raman signal amplification and protection from contaminations, respectively. The SF layer filtrated molecules larger than the nanopores created in the SF matrix. On the SF layer, the AgNW layer was formed in a random network structure with an average 200 nm thickness, creating a high density of hot-spots for SERS effect. Molecules penetrated through the SF layer reached the AgNW layer and then detected by a Raman laser through the transparent DP layer in a label-free method without patch detachment. The molecular detection capability and real-time diffusion properties of the wearable plasmonic sensor were imaged by high-resolution confocal microscopy and real-time Raman mapping. Then, the wearable plasmonic sensor patch was applied for illegal drug detection using 2-fluoro-methamphetamine (2-FMA), which is an analogue of methamphetamine, on human cadaver skin. The 2-FMA was detected down to a concentration of 50 pg/cm2 of the attached patch area. The developed wearable plasmonic sensor is expected to be applied for various flexible sweat sensor in purpose of drug surveillance and healthcare monitoring. |
