| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Nano Graphene Oxide – Hyaluronic Acid Conjugate/Epirubicin Complex for Target Specific Treatment of Cancer |
| 초록 |
Graphene oxide (GO) has been extensively investigated for various biomedical applications. In this work, nano-sized GO (NGO) was prepared and exploited for the target specific delivery of cancer therapeutics. Hexamethylenediamine conjugated hyaluronic acid (HA-HMDA) was tethered to NGO by amide bond formation using EDC. The HA-NGO conjugate showed enhanced stability and non-cytotoxicity in physiological condition. Epirubicin was loaded on graphitic domain of HA-NGO conjugates through π-π stacking. The controlled release of epirubicin from the complex in acidic endosomes resulted in the effective inhibition of tumor growth. The competitive binding tests with HA preincubation revealed the target specific delivery of HA-NGO/Epirubicin complex to CD44 positive B16F1 cells. Finally, the confocal microscopy for the co-localization of lysotracker and epirubicin in the endosome confirmed that the complex was delivered into the cells via receptor mediated endocytosis. |
| 저자 |
금도희1, 한세광1, 정호상2, 공원호2
|
| 소속 |
1POSTECH, 2포항공대 |
| 키워드 |
Graphene oxide; Hyaluronic acid; Epirubicin; Targeted delivery
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| E-Mail |
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