| 초록 |
In this study, we have investigated the interaction of water-soluble paclitaxel (7-mPEG5,000-succinyloxymethyloxycarbonyl-paclitaxel, PP7) prodrug and hen egg albumin(Mr ~45,000) by pulse-gradient field NMR (PFG-NMR). Diffusion coefficient of PP7 with Albumin in modified Hank's Balanced Salt Solution (MHBSS) was measured as a function of PP7 (0.0~1.7% w/w) and albumin (0.0~1.4% w/w) concentration at different temperatures. This study suggested that the results of molecular mobility and interaction can be used to determine the transport mechanisms in human body liquid. |
