| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Optimized Silk/PLGA Hybrid Films for Human Aortic Endothelial Cells Culture |
| 초록 |
A new compliant scaffold suitable for small-diameter vascular grafts has been developed that promotes strong attachment of endothelial cells. Silk will be used as a model protein for scaffold fabrication in this study due to its widespread versatility. Therefore, we fabricated hybrid polymeric films containing PLGA and various concentration of silk. The biocompatibility of silk/PLGA films was demonstrated by ELISA using TNF-α. The proliferation of cells studies supported the utility of this biomaterial films on HAECs. The preservation of cell phenotype on the silk/PLGA films was confirmed by the presence of cell-specific markers using immunocytochemistry and RT-PCR. The results indicate a favorable interaction between vascular cells and silk/PLGA films. These data confirm the potential of this novel hybrid films in vascular tissue engineering. This research was supported by WCU (R31-20029) and SCRC (SC4110). |
| 저자 |
조수진, 이지혜, 조원형, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Silk; Endothelial cells; PLGA
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| E-Mail |
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