| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Hypoxia Sensitive Activatable Fluorescence Imaging Probe based on Self-Immolative Dendrimer |
| 초록 |
Self-immolative dendrimer can undergo triggered degradation by a modified trigger which attached dendrimer core. End group of conjugated molecules undergoes domino-like degradation by the single triggered event of the self-immolative dendrimer. When a fluorescent dye was introduced at the end of the dendrimer, self-quenching caused by the FRET phenomenon. In this study, we modified the hypoxia-sensitive trigger to apply to diagnose hypoxic cancer. The most solid tumor has the hypoxic condition because it located far from blood vessels, which provides the conditions of low oxygen level and abnormal tumor tissue environment. Nitro group which modified in dendrimer core acts hypoxia-sensitive trigger, fluorescent dye was conjugated to dendrimer tail end. Nitro group undergo reduced by metabolic reduction at the hypoxic condition, cascade reaction progressed by carbamate linkage and release fluorescence dye which conjugated at the periphery of dendrimer and shows fluorescence recover. |
| 저자 |
정인재1, 이주형2, 조한희3, 안철희4
|
| 소속 |
1Research Institute of Advanced Materials (RIAM), 2Department of Materials Science and Engineering, 3College of Engineering, 4Seoul National Univ. |
| 키워드 |
Activatable imaing; Hypoxia; Cascade; Self-immolative; Dendrimer
|
| E-Mail |
|
