| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Development of Hypoxia-Activatable Optical Imaging Probe |
| 초록 |
Self-immolative dendrimer has well defined 3-D branched structure with designed for controlled release of various molecules. By the single trigger event release of conjugated molecules at the periphery of dendritic building blocks. If the conjugated molecules was a fluorescent dye, FRET-based self-quenched dye will show fluorescence recovery by the single triggered event. In this study, we modified self-immolative dendron to active at the hypoxic environment. Most solid tumor has a hypoxic condition, which provides the conditions of low oxygen level and abnormal tumor tissue environment. Nitro group which modified in dendrimer core acts hypoxia-sensitive trigger, fluorescent dye was conjugated to dendrimer tail end. Nitro group reduced by metabolic reduction at the hypoxic condition, cascade reaction progressed by carbamate linkage and release fluorescence dye and shows hypoxia sensitive fluorescence recovery. |
| 저자 |
정인재1, 이주형2, 조한희3, 안철희4
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| 소속 |
1Research Institute of Advanced Materials (RIAM), 2Department of Materials Science and Engineering, 3College of Engineering, 4Seoul National Univ. |
| 키워드 |
Hypoxia; Self-immolative; Cascade; Activatable optical imaging; Dendron
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| E-Mail |
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