| 초록 |
Currently, most of the patch type therapeutic agents have limitations in that the drug is not well controlled due to the structure of the film, so that the drug is not smoothly absorbed into the skin. In this work, nanofiber sheets (NS) as patch-type therapeutic agent using small intestinal submucosa (SIS) prepared by electrospinning. Nanofibers have a large surface area. The large surface area not only sufficiently constitutes the wet state but also has a three-dimensional structure, so that drug release is facilitated at the wound site. Also, SIS has excellent biocompatibility and is an ECM. In this experiment, the nanofiber morphology of the SIS-NS was evaluated by SEM. The absorbability of SIS-NS was evaluated by contact angle test. The cytotoxicity of SIS-NS was confirmed in vitro. Also, the skin wound healing effects of SIS-NS was evaluated by in vivo for 3 weeks. In conclusion, these results indicate that SIS-NS can be applied as a therapeutic agent for skin wound healing. |
