| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Characterization of pendant group-functionalized polycaprolactone for temperature-responsive hydrogels and biomaterial engineering |
| 초록 |
In biomaterial engineering, Polycaprolactone have attracted attention for temperature-responsive hydrogels functionality. In this study, we manufactured 4-benzyloxy-caprolactone (CL-OBn) to graft functional group to PCL and then ring opening polymerization was performed by using the hydroxyl group of methoxy polyethylene glycol (MPEG). We expected that it could be used as a biomaterial by using an acid catalyst which can be removed easily. The MPEG-PCL with benzyl pendant group (MC-OBn) was deprotected and replaced with a hydroxy group to finally produce MC-OH. The molecular weights and segment ratios of MC-OH were close to the theoretical values. Suspension of MC-OH was observed distinct sol-to-gel phase transitions as a function of the temperature and relied on the amount of pendant group. As a result, we demonstrated that functionalized polycaprolactone were successfully obtained and served as temperature-responsive hydrogels for biomaterial engineering. |
| 저자 |
지윤배, 주현진, 박준영, 박승훈, 김문석
|
| 소속 |
아주대 |
| 키워드 |
Polycaprolactone; Temperature-responsible hydrogels; Phase transition; Pendant group
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| E-Mail |
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