| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
대학원생 구두발표 (발표15분) |
| 제목 |
Paper-based Scaffold for Stem Cell Culture and Bone Regeneration |
| 초록 |
Stem cell behaviors are highly regulated by various biochemical and biophysical cues from cell-surrounding microenvironments. Here we report a new surface engineered-paper scaffold system by initiated chemical vapor deposition (iCVD) process. iCVD is a one-step, solvent-free method to coat functional polymer films conformally onto various substrates. A waterproof and cell-adhesive polymer film was serially coated on the micro-structured surface of paper. The surface modified paper scaffold system demonstrated excellent biocompatibility and improved mechanical robustness. It is also suitable for cell adhesion, proliferation, and gene transfection. Moreover, the developed paper scaffold system could facilitate enhanced in vitro osteogenic differentiation of human adipose derived stem cells (hADSCs). Transplantation of hADSCs cultured on paper scaffolds significantly promoted in vivo bone formation in critical-sized calvarial bone defects. |
| 저자 |
유승정1, 박현지2, 양기석2, 진윤희2, 조안나2, 양희석3, 조승우2, 임성갑1
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| 소속 |
1한국과학기술원, 2연세대, 3단국대 |
| 키워드 |
Paper; Stem cells; Initiated chemical vapor deposition; bone regeneration
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| E-Mail |
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