| 초록 |
Poly(lactic-co-glycolide) (PLGA) microspheres have been investigated for a long time as a protein/peptide delivery depot, and some products were already commercialized. However, recent publications have report about their disadvantages in the long term delivery of protein/peptide drugs such as the denaturation, aggregation, and deamidation of protein/peptide drug. The phenomena are induced by proton generated from the hydrolysis of ester linkages in PLGA. Therefore, the development of new protein/peptide delivery depot is necessary. In this study, pullulan acetate microsphere (PAM) was inspected as a depot for long term delivery of exendin-4 which is a drug for type II diabetes. It was prepared by w/o/w double emulsion method. The mean particle size of PAM ranged from 5 to 50 m , as determined by SEM. Their shapes were regular and spherical, as visualized via SEM photographs. The exendin-4 loading efficiency of the microspheres was up to 75wt. % . |
