| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Enhanced Properties of Pluronic F127 Hydrogel Using Ionic Interactions |
| 초록 |
Pluronic which exhibits thermally induced gelation behavior in aqueous solution have been attracted in biomedical field. Despite of its special property, there has been some limitations for its practical use due to poor mechanical strength. In physiological environment, preformed gel showed poor stability both in vitro and in vivo. In this study, we modified Pluronic, PEO-PPO-PEO triblock copolymer, by introducing chargable moieties at the each end of the copolymer. Blending carboxylated and aminated Pluronics at an optimum ratio resulted in the improvement of micelle packing ability between micelles ny ionic interaction in addition to hydrophobic interaction. 1H-NMR spectra analysis concluded that the modified Pluronics were successfully synthesized with high degree of substitutions. Using dynamic mechanical analysis, ionically blended Pluronic hydrogel was confirmed to show higher modulus than Pluronic hydrogel at the same concentration. |
| 저자 |
이승용1, 채수영2, 박태관3, 안철희1
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| 소속 |
1서울대, 2성균관대, 3KAIST / 생명과학과 |
| 키워드 |
F127; Pluronic; hydrogel; ionic interaction
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| E-Mail |
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