| 초록 |
Organic/Inorganic hybrid nanoparticles have emerged as novel nanoplatforms in biomedical resesarch field due to their inorgnic properties like high stability and optical properties and organic characteristics like biodegradability, flexibility of molecular design. Especially, gold-based hybrid nanoparticles have shown great potential as a nanoplatform for photothermal or photodynamic therapy owing to their biocompatibility and optically activatable properties. Herein, we demonstrate a biostable, photo- and enzyme-activatable hybrid nanomaterial based on a gold-nanoclustered hyaluronic acid nanoparticles (GNc-HANPs) that can be employed as a potent photodynamic therapy agent and as a photothermally activatable photodynamic therpay nanoformulation. The physicochemical and biological characteristics were investigated in detail using various analytical methods such as 1H-nuclear magnetic resonance (1H-NMR), transmission electron microscopy (TEM), dynamic light scattering (DLS), UV/VIS spectrophotometer and confocal microscopy and near-infrared fluorescence (NIRF) system. Overall, these results suggest that photothermally maneuvered photodynamic therapy using GNc-HANPs can provide potential therapeutic tools to eradicate tumors. |
