| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
고분자가공/복합재료 |
| 제목 |
Soft Implantable Device Embedded with Multi-channels and Reservoirs for Controlled Drug Delivery |
| 초록 |
Implantable drug delivery devices for the treatment of chronic diseases can be more advantageous when enabled with controlled drug delivery and high patient compliance. However, the devices are mostly made of hard materials that may need large incision size and cause discomfort after implantation. To resolve these, we developed an implantable device made of a soft polymer, polydimethylsiloxane (PDMS). For controlled drug delivery, multiple pairs of channels and drug reservoir were embedded in the device. In channels, a biocompatible hydrogel, gelatin was filled to serve as a drug diffusion barrier. By varying the lengths of channels, we sought to precisely control a drug release profile and onset time. The drug release onset time and rate could be modulated from day 1 to day 14 and from 0.4 %/day to 4.3 %/day, respectively. In pharmacokinetics study, the average drug concentrations in the blood serum were observed to be maintained within a narrow range of 44-103 ng/ml. |
| 저자 |
지한비, 김세나, 이승호, 김초림, 조용찬, 한재훈, 최영빈
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| 소속 |
서울대 |
| 키워드 |
controlled drug delivery; implantable device
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| E-Mail |
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