| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
[콜로이드·계면화학] 피부 바이오 혁신연구동향 |
| 제목 |
7,3',4'-trihydroxyisoflavone (7,3',4'-THIF), a mineralocorticoid receptors antagonist, improves skin barrier dysfunction by psychological stress |
| 초록 |
Endogenous glucocorticoids (GC) binds mineralocorticoid or GC receptors (MR or GR) after conversion cortisone (inactive form) to cortisol (active form) by 11β-hydroxysteroid dehydrogenase type I (11ß-HSD1). Here, we examined whether MR antagonists can ameliorate GC-mediated skin barrier dysfunction in normal human epidermal keratinocytes (NHEKs), reconstructed human epidermis (RHE), and subjects under psychological stress (PS). We identified 7,3',4'-THIF ameliorated the cortisol effect and improved skin barrier function on PS subjects. |
| 저자 |
손의동1, 최은정1, 이한일2, 김은정2, 김형준1, 박원석1, 강영규1, 김진철3, 김수남3, 최응호2
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| 소속 |
1아모레퍼시픽 기술(연), 2연세대, 3한국과학기술(연) |
| 키워드 |
psychological stress; skin barrier; cortisol
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| E-Mail |
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