| 초록 |
AP736 exhibited potent effects in the inhibition of tyrosinase and melanin synthesis. However, it is hard to formulate due to its low aqueous solubility. In this study, we fabricated polymeric nanoparticles (PNPs) in order to incorporate AP736. Three different PEG-PCL copolymers with various chain lengths were used. The PNPs were characterized by measuring their size as well as encapsulation efficiency and loading content. We also investigated their release profiles through the permeation study. The PNPs had a mean size from 50nm to 200nm. Most of PNPs prepared with a combination of PEG-PCL copolymers and POE-type surfactants showed the good encapsulation efficiency up to 90. After encapsulation of AP736, no significant changes were observed in the sizes of tested PNPs within 4 weeks. Further, PNPs containing choleth-24 (2.06±0.29 μg /cm2 h) showed the faster release pattern compared to PNPs using Tween 80 and saturated in DI water. |
