| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Preparation of polymeric drug with Para-amino salicylic Acid and chitosan for utilization as Anti-tuberculosis Agent |
| 초록 |
Tuberculosis(TB) remains a major threat to global public health. Currently, para-aminosalicylic acid(PAS) had been used to cure of TB. However, utilization of PAS has a problem to therapy of TB that its curing effect is decreased by multi-drug resistant (MDR effect) against TB. To solve these problem, drug delivery system(DDS) is designed such as polymeric micelle and polymeric drug. It has a advantage that can be efficiently protected against MDR effect. In this study, we developed to PAS-grafted chitosan polymeric drug by coupling agent. Its chemical structure was analyzed by 1H-NMR, FT-IR, and UV-vis. In addition, critical aggregation concentration(CAC) and particle size were confirmed by fluorophotometer and DLS. Moreover, its cytotoxicity was evaluated by MTT assay.(Grant number)(NRF-2016H1D5A1910499) |
| 저자 |
남충현, 최창용, 정경원, 홍웅길, 안준혁, 나재운
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| 소속 |
순천대 |
| 키워드 |
Tuberculosis; Para-aminosalicylic acid (PAS); Chitosan; Polymeric drug
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| E-Mail |
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