| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
Blood Coagulation-inspired Hyaluronic Acid Hydrogel for Multifunctional Hemostatic Agent |
| 초록 |
During surgical treatment, excessive blood loss can lead to lethal situations. Thus, proper hemostasis technique is crucial. This has led to the development of hemostatic agents for clinical uses. However, current hemostatic agents have several limitations related to biocompatibility and functionality. Here, we demonstrated a hydrogel system inspired by blood coagulation mediator in platelets as a hemostatic agent with improved performance and multifunctionality. The hydrogel facilitated blood coagulation and exhibited improved hemostatic capability in vivo. Also, it could act as an anti-adhesion layer to prevent abnormal tissue adhesion. In conclusion, our bioinspired hydrogel that overcomes shortcomings of existing hemostatic agents could effectively control bleeding and provide multifunctionality, thereby improving clinical outcomes. This work was supported by a grant (2018M3A9H1021382) from the National Research Foundation of Korea funded by the Ministry of Science and ICT, Korea. |
| 저자 |
안수환, 전지훈, 한승엽, 김수연, 민성진, 조승우
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| 소속 |
연세대 |
| 키워드 |
hydrogel; hyaluronic acid; hemostatic agent; anti-adhesion
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| E-Mail |
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