| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Synergistic Effect of Electrical Ablation with Functional Nanoparticles in Cancer Treatment |
| 초록 |
Recently developed electrical ablation (EA) is a tumor treatment technology that induces apoptotic cell death of cancer cells by giving pulsed electronic fields to desired areas without using thermal energy. Especially, the damaged cancer cells by the EA can generate damage-associated molecular patterns (DAMPs) to induce anti-cancer immune responses. In this study, we developed a combination therapy of EA and functional nanoparticles conjugated with immune adjuvants for improved cancer treatment efficacy. The nanoparticles were synthesized with core-shell structure and characterization by using TEM and DLS analyses. Through in vitro and in vivo experiments, it is demonstrated that the synergistic effect of EA with the functional nanoparticles significantly increase anti-cancer immune responses. Taken all together, we conclude that the combination of EA with functional nanoparticles has strong potential for various incurable cancer treatments. |
| 저자 |
한준혁1, 이아름1, 김익환2, 한동근1, 박우람1
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| 소속 |
1차의과학대, 2고려대 |
| 키워드 |
Electrical ablation (EA); Nanoparticles; Cancer immunotherapy; Immune adjuvants; Damage-associated molecular patterns (DAMPs)
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| E-Mail |
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