| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
NIR light-triggered drug release using biodegradable polymer fibers incorporated with indocyanine green and phase-changeable fatty acid for localized anti-cancer therapy |
| 초록 |
This study introduces a new system for NIR light-triggered release of drugs. The system consists of polycaprolactone (PCL)-based fibers havings a core loaded with doxorubicin (DOX) and a sheath incorporated with indocyanine green (ICG) as a NIR-absorbing agent together with a phase-changeable fatty acid. Upon NIR irradiation, the photothermal agent will generate heat to raise the local temperature of the fibers. When the temperature is above the melting point of the fatty acids, nano-pores will be generated in the fibers. This response to NIR irradiation allows the instant release of DOX from the fibers through the pores, leading to the significant increase of anticancer activity in combination with the hyperthermia effect arising from the photothermal agent. |
| 저자 |
박주향1, 현동춘1, 황세정1, 손진호1, 최지현1, 이호균2
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| 소속 |
1경북대, 2평화 오일씰 |
| 키워드 |
NIR-triggered drug release; PCL fiber; fatty acid; electrospinning; anticancer
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| E-Mail |
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