| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
On-off switchable fibrous system for NIR light-assisted cancer therapy |
| 초록 |
This research introduces a biocompatible polymer-based hollow fiber system for combination cancer therapy. The system consists of poly(D,L-lactic-co-glycolic acid) (PLGA) fibers with a core encapsulating anticancer drug and a shell incorporating gold nanorods (AuRDs) as a photothermal agent. Under NIR irradiation, the phoththermal agent generates heat to increase the local temperature of the fibers. If the temperature is higher than a glass transition temperature (Tg) of the polymer, the chains in polymer will be mobile, increasing free volume in size within the shell, leading to rapid release of the drug from the core. When NIR light is turned off, the release will be stopped with inactivity of the photothermal agent, followed by freezing the segmental motion of the polymer chains. The on-off switching of NIR light allows a repeated release of the drug, leading to the enhancement of anticancer activity in combination with the hyperthermia effect arising from the photothermal agent. |
| 저자 |
박주향1, 서호준2, 최지현1, 김다인1, 홍상기1, 김혜지1, 안형주3, 문건대4, 현동춘1
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| 소속 |
1경북대, 2한국생산기술(연), 3포항 가속기 (연), 4한국생산기술원 |
| 키워드 |
electrospinning; Poly(D; L-lactic-co-glycolic acid) (PLGA); Hyperthermia; cancer therapy; polymer chain mobility
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| E-Mail |
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