| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Tripeptide Assembly Phases on 2D Nanosheets as Artificial Antibodies for Theragnosis of Bacterial Infection Diseases |
| 초록 |
It is of great interest to design antibody mimics for the detection and inactivation of specific pathogenic bacteria. Herein, transition metal dichalcogenide (TMD) nanosheet interfaces were functionalized with tripeptide assemblies (TMD-TPs). TMD-TPs were characterized by FT-IR, XPS, and ICP, showing the characteristics of both TMDs and peptides. Various tripeptide assemblies were constructed on the TMDs surface, and the resulting TMD-TPs exhibited different bacteria recognition selectivity. TMD-TPs had great selectivity to target bacteria against ten different kinds of bacteria. In addition, TMD-TPs detected the target bacteria at the concentration as low as a single copy from human serum. By using surface shaving and competitive assays, the binding sites of the bacteria were found through thorough experiments and simulations. Finally, TMD-TPs effectively killed the pathogenic bacteria on the skin wounds of infected mice under nIR irradiation, leading to rapid wound healing. |
| 저자 |
강태욱, 이신, 황인준, 이현지, 최찬희, 김종호
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| 소속 |
한양대 |
| 키워드 |
Transition metal dichalcogenides; Surface modification; Selective detection; Pathogenic bacteria; Theragnostics
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| E-Mail |
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