| 초록 |
The aim of this study was to improve the osteogenic ability of sand-blasted 3D printed bullet shaped cage type titanium (Ti-6AI-4V) scaffold. We used demineralized bone matrix derived hydrogel (DBM) and TCP powder (TCP) to construct micro-scaffolds within the pores of porous titanium alloy (Ti). We compared three groups: Ti, Ti/DBM, and Ti/DBM/TCP. Morphology, chemical composition, phase, in-vitro biocompatibility and differentiation behavior of all scaffolds were studied. The Ti/DBM/TCP scaffold exhibited significantly higher protein expression of ALP and OPN. In-vivo biodegradation and bone regeneration efficacies of Ti, Ti/DBM, and Ti/DBM/TCP were also evaluated using a rabbit femur defect model for 1 month and 2 months. Ti/DBM/TCP group also exhibited the higher new bone volume at in-vivo results. The hybrid 3D micro-scaffold structure titanium may be used as an interbody fusion cage. |
