| 초록 |
This study demonstrates the usefulness of lithography-based ceramic 3D printing technique with a specifically designed top-down process for the production of porous calcium phosphate (CaP) ceramic scaffolds with tailored pore orientations and mechanical properties. The processing parameters, including the preparation of a photocurable CaP slurry with a high solid loading ( = 45 vol%), exposure time for photocuring process, initial designs of the porous scaffolds, were carefully controlled. Three types of porous CaP scaffolds with different pore orientations (i.e. 0o/90 o, 0o/45 o/90 o/135 o, and 0o/30o/60o/90o/120o/150o) were produced. All the scaffolds exhibited a tightly controlled porous structure with straight CaP frameworks arranged in a periodic pattern, while the porosity was kept constant. The porous CaP scaffold with a pore orientation of 0o/90o demonstrated the highest compressive strength and modulus due to a number of CaP frameworks parallel to the loading direction. On the other hand, scaffolds with multiple pore orientations may exhibit more isotropic mechanical properties, regardless of the loading directions. The porous CaP scaffolds exhibited excellent in vitro apatite-forming ability in a stimulated body fluid (SBF) solution. These findings suggest that porous CaP scaffolds with tailored pore orientations may provide tunable mechanical properties with good bone regeneration ability. |
