| 초록 |
Tumor microenvironments play critical roles in cancer progression and metastasis through various physicochemical and biological parameters. Recently, various bioinspired hydrogels have been utilized as engineered tumor microenvironments recapitulating the milieu cues in the native tumor extracellular matrices. Herein, we present interpenetrating polymer network (IPN) hydrogels composed of thiolated-gelatin and tyramine-conjugated poly (ethylene glycol) as long-term stable artificial tumor microenvironments. The hydrogels were formed via HRP-mediated dual cross-linking reactions, exhibiting controllable physicochemical properties. We encapsulated human fibrosarcoma (HT1080) cells into hydrogels to evaluate the effect of matrix stiffness on the cell proliferation and drug resistance against a 5-FU anticancer drug. In conclusion, our IPN hydrogels are considered as a promising platform to study cancer biology and to screen innovative therapeutic agents for better clinical outcomes. |
