| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Near infrared laser-triggered drug release from molecularly imprinted polymer PLA nanoparticles |
| 초록 |
Herein, we suggest the molecularly imprinted polymer poly(lactic acid) nanoparticles (MIP-PLA NPs) for drug release triggered by near infrared (NIR) laser. Melanin as a photo-heat conversion material and poly(N-isopropylacrylamide-co-acrylamide) (PNIPAM) as thermosensitive polymer were added into PLA NPs. 5-fluorouracil (5-FU) was imprinted to the surface of PLA NPs. MIP-PLA NPs had spherical shape and more rough surface than non-imprinted PLA NPs. To confirm selective recognition of 5-FU, uridine (UR) was loaded into MIP-PLA NPs. PLA NPs imprinted with 5-FU recognized selectively 5-FU more than UR. The temperature of MIP-PLA NPs rose above lower critical solution temperature (LCST) of PNIPAM after NIR 808 nm laser irradiation at 1.5 W/cm2 for 7 min. The release rate of 5-FU from MIP-PLA NPs increased rapidly after NIR 808 nm laser irradiation. These results indicate that the MIP-PLA NPs are expected to be useful as a drug carrier for releasing drugs by photo-heat conversion. |
| 저자 |
김예슬, 김민아, 이창문
|
| 소속 |
전남대 |
| 키워드 |
Molecularly imprinted polymer; Melanin; Photothermal effect; Drug release
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| E-Mail |
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