| 초록 |
A research on cell interaction is important in many biological processes such as quantified cell adhesion, cell aggregation and direct drug injection research area. Force−distance (F/D) curve-based AFM has enabled to quantify biophysical properties and biomolecular interactions on a wide variety of specimens. A unique feature of mussels-inspired DOPA material is their remarkable ability to stick to various wet surfaces. Hyaluronic acid(HA) and poly ethylene glycol(PEG) polymer have been widely utilized as a biocompatible and biodegradable material for drug delivery, tissue regeneration and wound healing. In this work, we have studied polymer coated AFM tip −cell membrane interactions by using atomic force microscope (AFM) based Force-distance mode. The surface of AFM probe was modified by the polymers (HA-DOPA and PEG-DOPA materials) which could interact with the cells. All characterization was performed by atomic force microscope and scanning electron microscope. |
