| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
Characterization of inhibitory effects of Akkermansia muciniphila on adipocyte differentiation and lipid accumulation by Integrative multi-omics analysis |
| 초록 |
A. muciniphila, known as next-generation probiotics, is reported to have a positive correlation with obesity. Although many positive effects related to obesity have been reported, only cell phenotypic changes or alterations of markers associated with obesity have been reported. In this study, the changes of biological mechanism in 3T3-L1 cells under treatment with the cell lysate of A. muciniphila were investigated by multi-omics-based approaches. A. muciniphila suppressed differentiation and lipid accumulation of 3T3-L1 cells in cellular level, and inhibitory effects were observed in mRNA expression levels, fatty acid production, proteomic and metabolomic analysis results. These observations indicated that the cellular components of A. muciniphila could be a valuable biotherapeutics on obesity. |
| 저자 |
김예림, 김윤곤, 조성현, 이재승, 권지은, 박지현, 백지현, 김민규, 권서영
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| 소속 |
숭실대 |
| 키워드 |
Akkermansia muciniphila; Adipocytes; Multi-omics
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| E-Mail |
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