| 초록 |
Here we report 1) the fabrication of a series of antibiofouling polymer-coated SPION that bear near IR dyes and doxorubicin (Dox) as an anticancer drug, and 2) their application to cancer imaging and therapy in vivo. When the SPION was administered to Lewis lung carcinoma tumor allograft mice by intravenous injection, the tumor was unambiguously detected in T2-weighted magnetic resonance images as a 68% signal drop as well as in optical fluorescence images within 4 h, indicating a high level of accumulation of the nanomagnets within the tumor site. At least 2 times higher accumulation of the anticancer drug, doxorubicin was observed at the tumor area with the Dox-loaded SPION compared to the case of free Dox. In addition, the DOX@TCL-SPION showed exceptional anti-tumor effects without any systemic toxicity. It is noteworthy that, despite the fact that TCL-SPION does not bear any targeting ligands on its surface, it was highly effective for tumor detection and therapy in vivo. |
