| 초록 |
A controlled drug delivery system for cancer has been fascinating these days owing to a massive amount of approach toward the system. Here, we designed a redox-responsive polymer dots, an “ON” fluorescence nanoparticle, and conjugated it with a fluorescent dye to achieve an “OFF” system caused by Förster resonance energy transfer (FRET) and follows it by the loading of a cancer drug for chemotherapy. The fluorescent of the system then recovers after reacting with cancer cell GSH (redox reaction) and simultaneously release the loaded drugs. In other words, the polymer dots intermolecular interaction is disturbed, and the cleavage of the functional group happened during exposure to GSH. These drug delivery system (DDS) offers a dual capability by only one stimulus owing to fluorescence “OFF/ON” behavior for bioimaging and controllable drug release which impacts to drugs amounts during delivery. |
