| 초록 |
Polydiacetylene (PDA), one of the responsive polymers, is an attractive material for sensors, bio-imaging and drug delivery system. By assigning this material, exhibiting blue-to-red color transition due to external stimuli, to supported lipid bilayer platform, it delivers selectivity in bio-molecular detection.To investigate time-dependent nanoscale phase behavior and color transition after antimicrobial peptide injection on SLB system, we adapted computational chemistry, especially coarse-grained (CG) molecular dynamics simulation. We conducted CG simulation with antimicrobial peptide on phospholipid-diacetylene system to present a crucial role of in regulating the degree of phase coexistence. In this study, we confrimed that the liquid-disordered phase of the system plays a critical role on increased detection capability against peptide. |
