| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis of Glycol Chitosan-reduced Gold Nanoparticles for Detection of Ischemic Stroke |
| 초록 |
Many researchers have studied about Gold nanoparticles(AuNPs). AuNPs are known for several advantages as a bio-material, specially, a computed tomographycontrast agent due to their high X-ray absorption. However, bare AuNPs are not stable enough in physiological condition and they only have weak targeting effect without a targeting moiety. For these reasons, it is necessary to modify surface of AuNPs. Glycol chitosan(GC) is one of the famous candidates for surface modification owing to their biocompatibility. GC was used as the reducing agent of AuNPs and the coating material to enhance stability of AuNPs. Ischemic stroke is a brain disease that clot stops blood supply to an area of the brain. Fibrin, one of the coagulation factors, can be a target of ischemic stroke imaging. GC-reduced AuNPs(GC-AuNPs) were reacted with fibrin-targeting peptide which targets the coagulation factor. Finally, we fabricated fibrin-targeting GC-AuNPs(Fib-GC-AuNPs) for effective ischemic stroke detection. |
| 저자 |
박성경1, 안철희1, 선인철2, 김광명2, 김동억3, 김정연3
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| 소속 |
1서울대, 2한국과학기술(연), 3동국대 |
| 키워드 |
Gold nanoparticles; Glycol chitosan; Ischemic stroke; fibrin-targeting
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| E-Mail |
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