| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
Coacervate-mediated tumor cell lysate delivery for immune cell activation and cancer vaccination |
| 초록 |
We developed a coacervate-mediated tumor cell lysate (TCL) delivery platform to strengthen the immune system through downstreaming vaccination against cancer. Due to the limitation of a single antigen-based cancer vaccination, TCL from carcinoma could show multi-epitope efficacy and induce effective activation of cytotoxic T lymphocytes and CD4+ T helper cells. Since TCLs are unstable and easily degraded after entering the body., coacervate (Coa) was utilized to encapsulate TCLs for enhancing bioacitivity and stability. Coa is composed of a biodegradable and biocompatible poly(ethylene arginyl aspartate diglyceride)(PEAD) cation and counterpart heparin (HEP) anion in an aqueous environment via electrostatic interaction. Coa-mediated TCL delivery could exhibit improved immunogenicity and cellular uptake efficiency toward bone marrow dendritic cells (BMDCs). By facilitated antigen presentation of BMDCs, subsequent T cell activation and improved vaccination will be investigated. |
| 저자 |
성지현, 김교범
|
| 소속 |
동국대 |
| 키워드 |
tumor cell lysate (TCL); Drug Delivery System; Coacervate(Coa); Dendritic cell(DC); Cancer vaccine
|
| E-Mail |
|
