| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
A Versatile Nanoconstruct Harnessing Tumor Retention, Permeation and Activatable Drug Release properties for Peritoneal Carcinomatosis treatment |
| 초록 |
Poor prognosis and low survival rate among peritoneal carcinomatosis (PC) patients prompted us to design a special drug delivery systems with high anti tumor activity and survival rate. Herein, we designed anti-cancer drug loaded glutathione responsive micelles that can enhance peritoneal retention time, penetrate tumor nodes and could release the drug in glutathione rich environment of cancer cells. Nanoparticles showed enhanced cellular uptake, cancer cell toxicity both in vitro and 3D tumor spheroids studies. Nanoparticles administered via intraperitoneal route demonstrated prolonged peritoneal retention and low systemic. Also, intraperitoneal chemotherapy showed significant inhibition of tumor nodes. Immunohistochemistry of tumor tissue demonstrated the high apoptosis and tissue damage. Overall, the design of drug loaded nanoparticles which could increase the peritoneal retention and tumor penetration proved to be an effective strategy for treating PC. |
| 저자 |
Cherukula Kondareddy1, 박인규2
|
| 소속 |
1Chonnam National Univ. Medical School, 2Chonnam National Universty |
| 키워드 |
Micelles; bile acid; glutathione; drug delivery; intraperitoneal chemotherapy
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| E-Mail |
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