| 초록 |
Biodegradable poly(lactide-co-glycolide) (PLGA) have found widespread use in modern medical practice. However, it's degradation rate is relatively slow for soft tissue regeneration especially to restore of skin and mucosa. The purpose of this study is to examine the effect of electron beam irradiation on degradation behavior of PLGA nanofibers. PLGA (50:50) nanofibrous mats were prepared by electrospinning, and were electron beam irradiated at various doses. The degradation behavior of the PLGA nanofiber was studied by measuring the changes in weight, FTIR spectra and surface properties. The results showed that morphology of electron beam irradiated PLGA nanofibrous mat was not deformed but hydroxyl group peak intensity was increased with increasing radiation dose during degradation experiments. From these results, a hydrolytic degradation is accelerating by electron beam radiation and biodegradation behavior of PLGA nanofibrous scaffold can be modulated with varying irradiation dose. |
