| 초록 |
Some of reactive oxygen species (ROS) are extremely toxic and act as key therapeutic molecules for cancer treatment. It is known that cancer cells are more vulnerable than normal cells to the oxidative stress, which is related to the increased generation of ROS. Thus, there have been many attempts to modulate the ROS level to kill the cancer cells. In particular, the Fenton reaction that amplifies the oxidative stress by generating hydroxyl radicals has been recognized as one of the powerful routes for effective cancer therapy. Herein, we develop a superoxide dismutase (SOD)-loaded mineralized nanoparticle that can intracellularly enhance the level of hydrogen peroxide (H2O2) and can trigger the subsequent conversion of H2O2 into highly toxic apoptosis-inducing hydroxyl radicals. This mineralized nanoparticle that enables enzyme-mediated oxidative stress amplification may find broad applications for the development of ROS-manipulating anticancer agents. |
