| 초록 |
Polymeric nanoparticles have been widely used in cancer therapy due to their potential tumor targeting ability and reduced undesirable toxicity. We hypothesized that a control of carbon dioxide generation from poly(lactic-co-glycolic acid) (PLGA) nanoparticles could regulate the release of anti-cancer drug loaded in the nanoparticles. PLGA nanoparticles containing both anti-cancer drug and mineralized calcium carbonate were prepared by the W/O/W emulsion method. Calcium carbonate was mineralized during the emulsion process by chemical reaction between calcium chloride and sodium carbonate dissolved in W1 phase and W2 phase, respectively. Once nanoparticles were taken by cells, carbon dioxide was generated due to the acidic microenvironments, which enhanced the release of doxorubicin from the nanoparticles. Controlled release of anti-cancer drug from gas-generating polymeric nanoparticles may provide a useful means to design novel drug delivery systems for cancer therapy. |
