| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
EGF-functionalized Au-melanin Nanoparticles for Photothermal Therapy |
| 초록 |
We report biocompatible nanoparticles synthesized from melanin and gold nanoparticles (Au-melanin) as photothermal agents for hyperthermic destruction of lung cancer cells. To direct these nanoparticles tocancer cells, Au-melanin nanoparticles were coated with polythene glycol conjugated with epidermal growth factors (EGF-PEG). These EGF-PEG@Au-melanin nanoparticles displayed high stability in serum, excellent cellular uptake, and non-toxicity towards cells. A549 cells were incubated with EGF-PEG@Au-melanin nanoparticles and exposed to 808 nm irradiation to induce photothermal effects. The nanoparticles successfully destroyed A549 cells after exposure to near-infrared light, but left different cell lines unharmed. Acknowledgements: the Basic Science Research Program (NRF-2013R1A1A1009626). |
| 저자 |
Ghasidit Pornnoppadol, 남윤성
|
| 소속 |
KAIST |
| 키워드 |
Melanin; Gold Nanoparticles; Epidermal Growth Factors; Photothermal Therapy
|
| E-Mail |
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