| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Oral delivery of Glucagon like peptide-1 encoding gene by antibody conjugated nanocarrier for type 2 diabetes treatment |
| 초록 |
Glucagon like peptide-1 secreted from pancreatic beta cells stimulates insulin production and suppresses glucagon secretion thereby lowering the blood glucose level to normal range. In type 2 diabetic patient, insulin secretion is hindered due to less functionality of GLP-1. We designed a GLP-1 gene delivery carrier which is conjugated to human IgG-Fc and able to delivery GLP-1 orally. The nanocarrier targets FcRn receptors that prolongs the half life time of the formulation, release GLP-1 gene in the small intestine, where GLP-1 is expressed and act on insulin production. We investigated the toxicity, in vitro cellular uptake and gene expression by the nanocarrier and even oral GLP-1 formulation delivery in diabetic mice could reduce the high glucose level and bring down to normal range. Thus, our formulation can be an efficient therapeutic tools for type 2 diabetes treatment. |
| 저자 |
Mohammad Nazmul Hasan1, 안정만2, 이용규2
|
| 소속 |
1한국교통대, 2Korea National Univ. of Transportation |
| 키워드 |
Glucagon like peptide-1; diabetes; antibody; type 2 diabetes
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| E-Mail |
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