| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Comparative study of different tethering of supported lipid bilayers surface coating of implantable biosensing devices |
| 초록 |
Supported lipid bilayers membranes are growing interest as models of biological membranes for coating of implantable biosensing devices. Because of the limitation of bilayers which directly supported on glass are separated from the substrate by a thin film of water, bilayer formation on the tethered surface is the choice. Here, we prepared coated gold substrate with tethered lipid bilayer. Firstly, gold coated glass substrates were tethered by different types of thiol lipids. Secondly, 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) was used for the formation of supported lipid bilayers. The successful surface modification was verified by FT-IR, confocal microscopy and FRAP assay. Antifouling assay was conducted with quartz crystal microbalance with dissipation (QCM-D) apparatus and fluorescence microscopy. The result demonstrates the successful formation of tethered lipid bilayer on gold substrate and provides suitable coating system of implantable biosensing devices |
| 저자 |
MD LEMON HASAN1, Mahmoud A. Elnaggar2, 정윤기3
|
| 소속 |
1Korean Institute of Science and Technology, 2Korea Institute of Science and Technology, 3한국과학기술(연) |
| 키워드 |
Implantable device; tethered lipid bilayer; surface coating; antifouling
|
| E-Mail |
|
