| 초록 |
We synthesized a new injectable thermogel, hexanoyl glycol chitosan (HGC), to enhance the efficiency of inner ear delivery of dexamethasone (DEX), and evaluated as an amphiphilic thermogel for use as a solubilizing agent as well as an injectable formulation for intratympanic delivery of the hydrophilic and hydrophobic forms of DEX. The physicochemical and thermogelling characteristics of the thermogel with different drug types and concentrations were investigated by 1H-NMR, ATR-FTIR, and rheometer. They demonstrated versatile release kinetics from several hours to more than 2 weeks, depending on the type and concentration of DEX. Moreover, our HGC thermogels showed good residual stability in the tissue for more than 21 days and delivered a considerably high drug concentration into the perilymph without cytotoxicity. Taken together, HGC thermogel could be applied as an effective and safe formulation for inner ear drug delivery. |
