| 초록 |
Peptoids are a unique class of peptide mimics based on oligoglycine scaffolding. As a bioinspired material, the properties of peptoids lie in-between natural biopolymers and nonnatural synthetic polymers. Like biopolymers, they are information-rich polymers, offering precise control of main chain length, side chain functionality, and monomer sequence. The structural similarity to polypeptides has been responsible for the impressive diversity of biological activity observed for peptoids; however, non-natural N-substituents render them higher stability than that of natural counterpart (i.e., protease-stable). Because peptoids are synthesized one monomer at a time from readily-available building blocks, an almost infinite sequence-space awaits to be explored. Given these exceptional properties, the potential applications of peptoid are not just limited to the field of biomedicine, but also can be found in the materials research. |
