| 학회 | 한국공업화학회 |
| 학술대회 | 2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 | 19권 1호 |
| 발표분야 | 정밀화학_포스터 |
| 제목 | Stereoselective synthesis of glutamate transporter blocker |
| 초록 | L-Glutamate is related to higher brain functions, such as memory and learning, but the role of its transporters has not been identified yet. One of the developed non-transportable blocker is L-threo-β-benzyloxyaspartic acid (L-TBOA), which is known as a specific extracellular amino acid transporter antagonist. We have recently developed a novel synthetic method for threo-β-amino-α-hydroxy acid, in which high stereoselectivity (more than 20:1) is observed from the intramolecular conjugate addition. Here, the developed synthetic protocol was applied to synthesize L-TBOA. The series of the reactions form the D-serinal derivative affords all the functional groups in L-TBOA efficiently. |
| 저자 | 서영란, 김영규 |
| 소속 | 서울대 |
| 키워드 | glutamate transporter blocker; L-TBOA |
