| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Applications of self-assembled PEGylated albumin nanoparticle in cancer chemotherapy and theranostics |
| 초록 |
Paclitaxel (PTX) is used as a major antitumor agent for the treatment of recurrent and metastatic breast cancer. The clinical application of PTX requires oil/detergent-based solvent due to its poor solubility in an aqueous medium. However, the formulation causes hypersensitivity reactions and limited tumor distribution. Herein, we introduce an oil-free method to prepare albumin-based PTX nanoparticles for systemic cancer therapy using a pegylated human serum albumin (HSA). Simple film casting and rehydration procedure produced PTX-incorporated self-assembled HSA-PEG nanoparticles. The HSA-PEG nanoparticle mediates efficient cellular delivery with the highest cytotoxicity in various breast cancer cell lines. When systemically administered in a mouse xenograft model for human breast cancer, the HSA-PEG nanoparticle formulation exhibited a long systemic circulation and enhanced intratumoral accumulation, resulting in a remarkable anticancer effect and prolonged survival of the animals. |
| 저자 |
김다훤, 임수연, LYU SIYAN, 황위보, 박채은, 김병덕, 정준구, 신주화, 이지현, 유빈, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
human serum albumin; oil-free formulation; pegylation; self-assembled nanoparticle; systemic cancer therapy; theranostics
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| E-Mail |
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