| 학회 |
한국화학공학회 |
| 학술대회 |
2016년 봄 (04/27 ~ 04/29, 부산 BEXCO) |
| 권호 |
22권 1호, p.524 |
| 발표분야 |
생물화공 |
| 제목 |
Dendrimer porphyrin-decorated Gold Nanoshells for Synergistic Combined Phototherapy of Cancer |
| 초록 |
Photodynamic therapy (PDT) is excellent method for the treatment of cancer. It involves the systemic administration of photosensitizers (PS) such as porphyrin and phthalocyanine, so PS transfers photon energy to generate cytotoxic reactive oxygen species (ROS) to kill cancer. In the case of photothermal therapy (PTT), it involves the conversion of absorbed photon energy into the heat by using gold nanomaterials. In this work, 3rd generation dendrimer porphyrin was deposited onto gold nanoshell coated silica nanoparticles via Layer-by-Layer method. The successful fabrication of this system was monitored by UV–Vis spectroscopy, high resolution TEM, and electrophoretic light scattering spectrophotometer. Also, photodynamic and photothemal effect of nanoparticles under light exposure was confirmed by conducting ROS generation and temperature increase test. Furthermore, synergistic combined phototherapy including PDT and PTT was achieved through cell viability using the MTT assay. |
| 저자 |
정의석, 김민수, 국윤민, 방혜정, 김은경, 장우동, 고원건
|
| 소속 |
연세대 |
| 키워드 |
의약생물공학; 기능성바이오/융합소재공학
|
| E-Mail |
|
| 원문파일 |
초록 보기 |
