| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
Biopolymer-Based Hybrid Materials for Sensing and Delivery |
| 제목 |
Metal Oxide and Hydroxide Nanoparticles as Contrast Enhancing Agents for Magnetic Resonance Imaging |
| 초록 |
Hollow nanoparticles with interior void spaces are attractive candidates for advanced MRI contrast agents owing to their large water-accessible surface area, which is able to carry high payloads of MR-active magnetic centers, and the ability of the interior void space to take up large amounts of drug molecules. The first part of this seminar will present our recent researche with hollow Mn3O4 nanoparticles (HMON) which show the greatly enhanced relaxivities and drug loading capacity, comparing with those having solid interior. I will discuss the development of a platform protocol for fabricating target-specific multimodality imaging probes based on T1 MRI contrast HMON. Their well-directed characteristics as a target specific imaging agent, including a successful in-vivo T1 contrast MRI diagnosis of cancer tissue, will be demonstrated. I will also present our approach for fabricating gadolinium based paramagnetic contrast agent from layered gadolinium hydroxide compound. |
| 저자 |
이인수 |
| 소속 |
포항공과대 |
| 키워드 |
Nanoparticle; MRI; Imaging agent
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| E-Mail |
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