| 초록 |
Bioactivable nano-carrier systems have shown excellent characteristics in-terms of high cellular uptake, target specificity, and efficient intracellular release mechanism. Here, we have developed a bioreducible biarmed poly(ethylene glycol)-triphenylphosphine conjugate, PEG-(TPP)2, for mitochondria targeting. Triphenylphosphine (TPP) molecules were chemically conjugated with biarmed linkages at one end of the PEG via disulfide bonds. The amphiphilic conjugate could self-assemble in aqueous media to form core-shell structured nanoparticles (NPs) with good colloidal stability and efficiently encapsulate a lipophilic anticancer drug, doxorubicin (DOX). Dox-loaded PEG-(TPP)2 NPs were characterized in terms of particle size, morphology, drug-loading and release behavior, and mitochondria targeting. Our results suggest that bioreducible Dox-loaded PEG-(TPP)2 NPs can induce fast drug release with enhanced mitochondria uptake, showing better therapeutic effect than non-reducible NP system. |
